Why can't the immune system eliminate Subacute Sclerosing Panencephalitis (SSPE) naturally? Understanding SSPE immune evasion.
Context Subacute Sclerosing Panencephalitis (SSPE) is a rare, progressive, and fatal inflammatory disease of the central nervous system caused by a persistent measles virus infection. Although the initial measles infection is usually cleared by the immune system, in rare cases, the virus can persist in the brain, leading to SSPE years later. A critical question is why the immune system, which is usually effective against measles, fails to eliminate the persistent virus in SSPE. This failure is multifaceted and involves viral characteristics, immune system impairments, and the unique environment of the brain. Simple Answer The virus hides inside brain cells where immune cells can't easily reach it. The virus changes slightly, making it harder for the immune system to recognize. The immune system in the brain is different and sometimes less effective. The virus can suppress some parts of the immune system. Brain inflammation caused by the virus can sometimes damage the immune respons...